Methylation«please contact us for all cost inquiriesEpigenetic methylation events are heritable modifications that regulate gene expression without altering the DNA sequence itself. They serve as regulatory mechanisms for a wide range of biological processes and genetic diseases, and irregular methylation patterns have been correlated with certain cancers. Methylation microarrays facilitate global investigation of regulatory events, in vivo, without the limitations of gene-specific analyses or the hands-on time required by chromatography-based methods.
>> Infinium Methylation Assays With Infinium Methylation Assays, researchers can quantitatively interrogate methylation sites at single-nucleotide resolution, profiling up to 12 samples in parallel to deliver high-throughput power while minimizing the cost per sample. The HumanMethylation27 BeadChip lets researchers interrogate 27,578 CpG loci, covering more than 14,000 genes. The 450K Infinium Methylation BeadChip offers a unique combination of comprehensive, expert-selected coverage of >450,000 methylation sites, high throughput, and low price, making it ideal for screening genome-wide association study (GWAS) populations. Sample Requirements: 500ng-1ug gDNA (with bisulphite conversion)
Agilent offers DNA methylation technology for biological research. The microarrays allow the monitoring of methylation events within CpG Islands, near promoters of human and mouse genomes, or defined regions such as those found in ENCODE .Click here for more Sample Requirements: 5ug gDNA (includes MeDIP)
Roche NimbleGen provides affinity-based methods for enrichment of methylated DNA fragments, such as MeDIP (Methylated DNA immunoprecipitation) or the MBD (Methyl Binding Domain Protein) methods, which are the preferred sample preparation methods for identifying methylated DNA on NimbleGen arrays. Sample Requirements: High-quality DNA generated using the MeDIP (methylated DNA
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